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AGILE: Publications and Other Outputs

Publications

OutputTitleJournal/ConferenceDate PublishedPublication Link
CST2Optimal dose and safety of molnupiravir in patients with early SARS-CoV-2: a phase 1, open-label, dose-escalating, randomised controlled studyInternational Workshop on Clinical Pharmacology of HIV, Hepatitis and Other Antiviral Drugs 202120 September 2021Read More
CST3AAn open label, adaptive, phase 1 trial of high-dose oral nitazoxanide in healthy volunteers: an antiviral candidate for treatment of COVID-19International Workshop on Clinical Pharmacology of HIV, Hepatitis and Other Antiviral Drugs 2021. Oral20 September 2021Read More
CST2Saliva, nasal & tear PK of EIDD-1931 in patients with COVID-19 receiving molnupiravirCROI 202115 February 2022Read More
PlatformThe AGILE Platform: Accelerating phase I/II evaluation of SARS-CoV-2 antiviralsInternational Pandemic Sciences Conference10-11th July 2023
CST8Saliva, nasal & tear PK of ritonavir-boosted nirmatrelvir (Paxlovid) in combination with molnupiravir in patients with laboratory-confirmed COVID-19International Workshop on Clinical Pharmacology of HIV, Hepatitis, and Other Antiviral Drugs11-13th September 2023
CST6Development, validation and application of a novel LC-MS method for quantification of favipiravir ribofuranosyl-5’-triphosphate (F-RTP) in human peripheral blood mononuclear cells (PBMCs)International Workshop on Clinical Pharmacology of HIV, Hepatitis, and Other Antiviral Drugs11-13th September 2023
CST5A randomised, adaptive Phase I study to determine the Phase II dose of Vir-7832: AGILE CST5CROI 20243-6th March 2024
CST8AGILE CST-8 Phase I Trial of Combined Nirmatrelvir/r and Molnupiravir for COVID-19CROI 20243-6th March 2024
CST6Favipiravir Pharmacokinetics in Saliva, Tears and Nasal Secretions of Hospitalised COVID-19 Patients Following Intravenous Favipiravir AdministrationInternational Workshop on Clinical Pharmacology of HIV, Hepatitis, and Other Antiviral Drugs18-19th September 2024
CST6Intracellular Pharmacokinetics of Favipiravir-5’- Ribofuranosyl Triphosphate in People with COVID-19CROI 20259-12th March 2025
PlatformAGILE-ACCORD: A Randomized, Multicentre, Seamless, Adaptive Phase I/II Platform Study to Determine the Optimal Dose, Safety and Efficacy of Multiple Candidate Agents for the Treatment of COVID-19: A structured summary of a study protocol for a randomised platform trialTrials19 June 2020Read more
CST2Optimal dose and safety of the novel oral anti-viral molnupiravir in patients with early SARS-CoV-2: a phase 1, dose-escalating, randomised controlled studyJournal of Antimicrobial Chemotherapy27 August 2021Read more
PlatformAGILE: A Seamless Phase I/IIa Platform for the Rapid Evaluation of Candidates for COVID-19 treatment: An update to the structured summary of a study protocol for a randomised platform trial letterTrials26 July 2021Read more
PlatformPractical recommendations for implementing a Bayesian adaptive phase I design during a pandemicBMC Medical Research Methodology20 January 2022Read more
CST2The development and validation of a novel LC-MS/MS method for the simultaneous quantification of Molnupiravir and its metabolite ß-d-N4-hydroxycytidine in human plasma and salivaJournal of Pharmaceutical and Biomedical Analysis02 September 2021Read more
CST3AAn open label, adaptive, phase 1 trial of high-dose oral nitazoxanide in healthy volunteers: an antiviral candidate for SARS-CoV-2Clinical Pharmacology & Therapeutics26 October 2021Read more
CST2Pharmacokinetics of ß-d-N4-hydroxycytidine, the active metabolite of prodrug molnupiravir, in non-plasma compartments of patients with SARS-CoV-2 infectionClinical Infectious Diseases10 March 2022Read more
CST2A Randomised -Controlled Phase 2 trial of Molnupiravir in Unvaccinated and Vaccinated Individuals with Early SARS-CoV-2The Lancet ID19 October 2022Read more
CST2Characterisation of SARS-CoV-2 genomic variations in response to molnupiravir treatment in the AGILE Phase IIa clinical trialNature Communications26 November 2022Read more
CST6Development and validation of an LC-MS/MS method for quantification of favipiravir in human plasmaJournal of Pharmaceutical and Biomedical Analysis05 September 2023Read more
PlatformApplication of novel plasma separation filter cards for quantification of NRTI di/triphosphates in DBS using LC-MSBioanalysis09 June 2023Read more
CST6A novel LC-MS/MS method for the determination of favipiravir ribofuranosyl-5’-triphosphate (T-705-RTP) in human peripheral mononuclear cellsJournal of Pharmaceutical and Biomedical Analysis01 August 2024Read more
PlatformOptimization of SARS-CoV-2 culture from clinical samples for clinical trial applicationsmSphere01 November 2024Read more

Related Publications

TitleJournalDate PublishedPublication Link
Application of novel plasma separation filter cards for quantification of NRTI di/triphosphates in DBS using LC-MSBioanalysis09 June 2023Read More
Prescribing Nirmatrelvir-Ritonavir: how to recognise and manage drug-drug interactionsAnnals of Internal Medicine01 March 2022Read More
Shutting the gate before the horse has bolted: is it time for a conversation about SARS-CoV-2 and antivrial drug resistance?Journal of Antimicrobial Chemotherapy18 June 2021Read More
Dose prediction for repurposing nitazoxanide in SARS-CoV-2 treatment or chemoprophylaxisBritish Journal of Clinical Pharmacology21 October 2020Read More
Pharmacokinetic modelling to estimate intracellular favipriavir ribofuranosyl-5′-triphosphate exposure to support posology for SARS-CoV-2Journal of Antimicrobial Chemotherapy02 June 2021Read More
Antiviral activity of molnupiravir precursor NHC against SARS-CoV-2 variants of concern (VOCs) and its therapeutic window in a human lung cell modelPreprint24 November 2021Read More